Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article

Muthanna Medical Journal
Volume 7, Issue 1,  2020 Page 20-26

Research Article

Dalia Abdalkader Shakur1, Suhad Faisal Hatem Al-Mugdadi2*, Inam S. Arif1

* Correspondence author:
1Mustansiriyah University/ College of Pharmacy/ Department of Pharmacology and Toxicology, Iraq, 2Mustansiriyah University/ College of Pharmacy/Department of Clinical Laboratories sciences /Iraq
Received 25 May 2020; accepted 10 June 2020; published 13 June 2020
This is an article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. Copyright © 2020 WK


Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.
Keywords:Cisplatin, Cancer, Molecular and Immunomodulatory effects, Genes repair

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