Prognosis of breast cancer patients and survival rate related with Ki-67 proliferation index: multicenter retrospective study

Muthanna Medical Journal
Volume 8, Issue 2,  2021 Page77-85

Sanjay D. Dandona 1, Velusamy Mohanty 2, Samarasimha Ganeshkumar 1*

* Correspondence author:
1Indian Council of Medical Research, New Delhi, India
2Institute of Public Health, India
Received August 11, 2021; revised October 09, 2021; accepted November 03, 2021; published November 22, 2021
Copyright © 2021 Samarasimha, et al. This is article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Breast cancer commonest cancer of urban Indian women and the second commonest in the rural women. It has different epidemio-clinical characteristics compared with European countries. The purpose of this study is to investigate prognosis and survival rate of breast cancer patients related with Ki-67 proliferation index in multicenter through retrospective study. We reviewed all patient’s data in registration center of Medical Oncology Departments, in the period 2016-2020. Data has been collected on 760 breast cancer patients. Our resulted data showed most prevalent comorbidities associated with breast cancer were cardiovascular diseases, diabetes and anemia. Ki-67 index >28% mostly associated with early age female, lymph node involvement (p=0.001), advanced tumor grade (p=0.00012) and risk of relapse (p=0.004). Survival rate was decreased in patients with (ER, PR, Her2 negative (triple negative breast cancer.

Keywords: Ki-67 index, Breast cancer, Retrospective study