Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

Muthanna Medical Journal

Volume 10, Issue 1,  2023 Page 14-37
http://dx.doi.org/10.52113/1/1/2023-14-37

Karmand Qadir Hamad Amin 1, Makwan Mohammed Abdulkareem 2*, Mohammed Omer Mohammed 3, Hersh Hayder Hama Ali 1, Amanj Abubakir Khaznadar 3 ,  Abdulla Sharief Abdulla 3, Serwan Mohammed Ismail 3 

Correspondence author: makwanjaff89@gmail.com
¹Internal Medicine Teaching Hospital, Sulaimani Directorate of Health
2 Sulaimani Mental Health Center, Sulaimani Teaching Hospital
3 Faculty of Medical Sciences, University of Sulaimani
Received 11 October 2022, Revised 31 December 2022, Available online 10 January 2023.
Copyright © 2023 MM. This is article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Abstract

COVID-19 is a viral disease that affects multiple body organs. The objective of this study is Investigating the role of PCT and CRP in predicting the outcome of patients with COVID-19. Cross-sectional prospective study including 135 patients with SARS-CoV-2 confirmed by RT-PCR. Serum level of PCT and CRP are measured at admission and on day 10 post-admission. Patients are followed up for one month. The mean level of PCT on day 1 was 0.1±0.28 ng/ml compared with 0.3±1.27 ng/ml on day 10. Respectively, the mean serum level of CRP on day 1 and day 10 was 113.57±89.88mg/L and 44.76±43.29 mg/L. At admission, the mean serum level of PCT and CRP in dead patients was 0.22±0.6 ng/ml and 164.0±105.59 mg/L, respectively compared with 0.07±0.08 ng/ml and 101.42±82.03 mg/L, respectively in the survived group. After 10 days of admission, the median serum level of PCT and CRP in dead patients was 1.5±2.74 ng/ml and 70.9±57.87 mg/L. respectively compared with 0.13±0.23 ng/ml and 37.7±34.87 mg/L, respectively in the survived patients. In conclusion, the serum level of PCT and CRP increases from admission to day 10 post-admission, and they are considered as indicators of severe inflammatory response and could increase mortality risk.

Keywords: SARS, SARS-COV-2, RT-PCR, Procalcitonin (PCT), C-CRP