Procalcitonin and C-Reactive protein levels among COVID-19 patients in Sulaymaniyah

Muthanna Medical Journal

Volume 10, Issue 1,  2023 Page 14-37

Karmand Qadir Hamad Amin 1, Makwan Mohammed Abdulkareem 2*, Mohammed Omer Mohammed 3, Hersh Hayder Hama Ali 1, Amanj Abubakir Khaznadar 3 ,  Abdulla Sharief Abdulla 3, Serwan Mohammed Ismail 3 

Correspondence author:
¹Internal Medicine Teaching Hospital, Sulaimani Directorate of Health
2 Sulaimani Mental Health Center, Sulaimani Teaching Hospital
3 Faculty of Medical Sciences, University of Sulaimani
Received 11 October 2022, Revised 31 December 2022, Available online 10 January 2023.
Copyright © 2023 MM. This is article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited


COVID-19 is a viral disease that affects multiple body organs. The objective of this study is Investigating the role of PCT and CRP in predicting the outcome of patients with COVID-19. Cross-sectional prospective study including 135 patients with SARS-CoV-2 confirmed by RT-PCR. Serum level of PCT and CRP are measured at admission and on day 10 post-admission. Patients are followed up for one month. The mean level of PCT on day 1 was 0.1±0.28 ng/ml compared with 0.3±1.27 ng/ml on day 10. Respectively, the mean serum level of CRP on day 1 and day 10 was 113.57±89.88mg/L and 44.76±43.29 mg/L. At admission, the mean serum level of PCT and CRP in dead patients was 0.22±0.6 ng/ml and 164.0±105.59 mg/L, respectively compared with 0.07±0.08 ng/ml and 101.42±82.03 mg/L, respectively in the survived group. After 10 days of admission, the median serum level of PCT and CRP in dead patients was 1.5±2.74 ng/ml and 70.9±57.87 mg/L. respectively compared with 0.13±0.23 ng/ml and 37.7±34.87 mg/L, respectively in the survived patients. In conclusion, the serum level of PCT and CRP increases from admission to day 10 post-admission, and they are considered as indicators of severe inflammatory response and could increase mortality risk.

Keywords: SARS, SARS-COV-2, RT-PCR, Procalcitonin (PCT), C-CRP