The effect of vit D3 deficiency on increased incidence of convulsion in epileptic patients

Muthanna Medical Journal

Volume 10, Issue 1,  2023 Page 93-98

Musaed Hekmat Al-dahhan ¹

Correspondence author:
¹ Al Muthanna University, College of Medicine, Department of surgery
Received 13 January 2023; revised February 21, 2023; accepted 26 March 2023, available online 24 April 2023.
Copyright © 2023 Al-dahhan, et al. This is article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited


Epilepsy is a common neurological disorder affecting all age groups We sought to assess the longitudinal effect of antiepileptic drug on serum 25-hydroxyvitamin D [25(OH)D], with recurrent attack of epileptic fits. The study consisted of two parallel, 1-year, prospective, randomized, dose-ranging trials conducted in two groups of ambulatory patients, for 46 patients based on clinical presentation of the patient together with confirmed diagnosis by EEG. The patients improved when maintenance dose of Vit D3 with daily taken to restore the normal level, with measurements for all patient 95 % of patient recovered from an epileptic fits with increase the level of Vit D3 to the normal value. In conclusions, majority of the patients should be treated with an escalating regimen of vitamin D, with doses varying between 400 and 15,000 IU/day.

Keywords: Epilepsy, Vitamin D3, Anti-conversant, Deficiency