Stem cell and growth factor-based regenerative therapies for reduced osteoarthritis pathogenesis

Posted on by Muthanna Medical Journal

Research article

Volume 11, Issue 1,  2024.  Page 27-36    10.52113/1/1/2024-1-36

Authors
Nasser Ghaly Yousif 1,2*, Wejdi Abbass Yassin Al-Fatlawy 3, Fadhil G. Alamran 4, Ahmed Altmimi 5, Christl Singh 6    

*Correspondence author: yousif_ghaly@mu.edu.iq
1 *Department of Medicine, College of Medicine, Al-Muthanna University
2  EX. University of Colorado Denver, Department of Medicine and Surgery Aurora, USA
3 Department of Surgery, Medical College, Kufa University, Kufa, Iraq
4 Department of Cardio-thoracic and Vascular, Medical College, Kufa University, Kufa, Iraq
5 Department of Biology, Ministry of Health, Iraq
6 Department of Hematology, Healthcare Global, Bangalore India. 
Received 12 November 2023; revised 11 March 2024; accepted 21 March 2024, available online 12 April 2024.
Copyright © 2024 Yousif, et al. This is article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Abstract

Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis (OA). In this article, we highlight recent work that addresses the key challenges of stem cell-based therapies for OA and provide examples of innovative ways in which stem cells can aid in the treatment of OA. Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment, and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity, and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating OA.

Keywords: Osteoarthritis (OA), Stem cell, Regenerative medicine

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Volume 10, Issue 2, 2023

 

 

 

 

Volume 11, Issue 1, 2024

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Nasser Ghaly Yousif NG, Al-Fatlawy WA, Alamran FG, Altmimi AN, Singh C. Stem cell and growth factor-based regenerative therapies for reduced osteoarthritis pathogenesis . Muthanna Medical Journal. 2024; 11(1):27-36.