Antimicrobial study of azo-imidazole (five cycles) compounds

Muthanna Medical Journal

Volume 4, Issue 2, November 2017, Pages 97-104

http://dx.doi.org/10.18081/2410-4590/2017-97-104

Research Article

Samah Ahmed Kadhum¹*, Aseel Fadhil Kareem²

¹*Head of Department of Clinical Laboratory Science, College of Pharmacy, University of Babylon

²Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon Received 02 July 2017, Accepted 12 October 2017, Available online 10 November 2017

This is article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 SK

Abstract

Azo-imidazole compounds are class of important organic compounds that are containing ( azo group with imine group, hetero cycles with hetero atoms ) which considered to be the previously derivatives that have pharmacological and biological activities toward many types of pathogenic organisms due to their content of nitrogen and chlorine atoms in their structures. We prepared four types of azo- imidazole derivatives (C15, C16, C17 and C18) at three different concentrations (5, 10 & 20 mg/ml-1) to study their antimicrobial activity against two types of bacteria (E. coli and P. vulgaris) and two types of fungi (A. niger & P. chrysogenum) and we found the best derivatives antibacterial and anti-fungal activity were (C16 and C18) at concentration (20 mg/ml-1) compared with other types through their ability to inhibit the growth of microbial isolates.

Keywords: Azo–imidazole; Antibacterial activity; Anti-fungal activity

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