Dyslipidemia in chronic renal failure

Abstract

Dyslipidaemia is a well documented and a common finding in patients with  CRF and its prevalence is higher than in general population. Lipid profile has been studied in 50 patients with CRF excluding    patients on hemodialysis or renal transplantation, and in 48 normal subjects of matched age and sex as a control. Also the proteinuria in GUE was assessed and a history of hypertension was evaluated in patients group. Dyslipidemia was found in 80{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} of patients with CRF who have significantly higher s. triglyceride and VLDL-C and lower HDL-C levels than control (P value <0.0005 for triglyceride and HDL-C and < 0.005 for VLDL-C). The commonest abnormality was hypertiglyceridemia (56{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). The frequencies of other lipid abnormalities were as follows: low HDL-C level (52{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}), high LDL-C level (32{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}), and hypercholesterolemia (22{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). Among patients with abnormal lipid profile, 70{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} of them have hypertension, and the same percentage have proteinuria. The dyslipidemia distributed evenly along the course of renal failure, so it can occurs in the early course of CRF as well as in the late one. In conclusion, dyslipidaemia is present in a significant number of patients with CRF regardless of the duration of renal failure; also it is significantly associated with hypertension and/or proteinuria.

Key words: Dyslipidemia; Hypercholesterolemia; Chronic renal failure

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