Physiological appraisal of glipizide in rabbits – Muthanna Medical Journal (MMJ)

Research article

Volume 11, Issue 1, 2024. Page 21-26 10.52113/1/1/2024-1-26

Authors
Wissam Sajid Hashim^*1, Nadia Abdullatif Ali Hassan², Jala Amir Salman Alahmed³

*Correspondence author: dr.w80@mu.edu.iq

¹ ^*Department of Physiology and medical Physics, College of Medicine, Al-Muthanna University

²Bilad Alrafidain University College

³Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basra

Received 20 October 2023; revised 3 February 2024; accepted 11 March 2024, available online 7 March 2024.
Copyright © 2024 Al-Taay. This is article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Abstract

Forty adult male rabbits were adopted to evaluate the squelae of the use of Glipizide. The results have revealed that streptozotocin causes significant declination in red blood cells count RBC, hemoglobin HB, packed cells volume PCV, alanine aminotransferase ALT, alkaline phosphatase ALP, glutathione GSH, triacylglycerols TAGs and high density lipoprotein HDL besides a significant elevation in total white blood cells count WBC, erythrocyte sedimentation rate ESR, malondialdehyde MDA, and low density lipoprotein LDL. For the Glipizide alone, it causes significant declination in RBC, Alanine aminotransferase AST, GSH, TAGs and VLDL besides a significant elevation in WBC, ESR, total cholesterol TC and LDL. Considering the use of Glipizide plus streptozotocin, it causes a significant declination in RBC, HB, PCV, GSH and HDL besides a significant elevation in WBC, ESR, LDL, TAGs, and VLDL.

Keywords: Glipizide, Streptozotocin, Diabetes, Rabbits

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