Comparison between eosinophilic and neutrophilic asthma

Posted on by Muthanna Medical Journal

Research article

Volume 11, Issue 2,  2024.  Page 135-146    10.52113/1/1/2024-2-146

Authors
Naji Ali Talib Al-Anbaky *1, Mohammed Waheeb Al-Obaidy 2    

*Correspondence author: mustafaeskander85@gmail.com

*1 Baghdad teaching hospital, Baghdad, Iraq.
2 College of Medicine, University of Baghdad, Baghdad, Iraq
 Received 22 July 2024; revised 30 August 2024; accepted 22 September 2024, available online 18 October 2024.
Copyright © 2024 al-Anbaky, et al. This is article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Abstract

Asthma is a common respiratory disease in general population that can be further subdivided into several cellular endotypes depending on sputum cell counts. The objective of this study to conduct a comparative analysis of eosinophilic and neutrophilic asthma endotypes in terms of their respective prevalence rates, patient characteristics, severity, and treatment response. Cross-sectional study included 59 patients with asthma who attended respiratory diseases out-patient clinic in Baghdad medical hospital between October 2022 and October 2023. The study included patients between 18 and 80 years with clinical history of asthma. Sputum sample was obtained from each patient and analyzed. In a study of 59 asthma patients, those with eosinophilic asthma had significantly younger ages and higher levels of blood basophils and sputum macrophages compared to those with neutrophilic asthma, who showed better asthma control. Significant correlations were found between sputum and blood eosinophils, as well as between sputum and blood neutrophils in eosinophilic and neutrophilic asthma, respectively. Other parameters did not show significant differences between the groups. In conclusion, Eosinophilic asthma is highly prevalent and poorly controlled. Patients with neutrophilic phenotype of asthma tend to be older than those with eosinophilic asthma.

Keywords: Asthma, Eosinophilic, Neutrophilic, Endotypes

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Volume 11, Issue 2, 2024

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Al-Anbaky N, Al-Obaidy M. Comparison between eosinophilic and neutrophilic asthma. Muthanna Medical Journal. 2024; 11(2):135-146.