Article Type
Article
Abstract
Background: HMSA was prepared as a new hydroxyazo ligand with an N, O, O donor arrangement, then used to form Mn (II), Ni (II), and Ag(I) complexes. Objective: The work examined the structural features of HMSA and the prepared metal derivatives and compared their biological responses. Materials and methods: CHNS analysis, FT-IR, UV–Visible and NMR spectroscopy, powder X-ray diffraction (XRD), and FE-SEM were used for characterization. Antibacterial, DPPH antioxidant, and cytotoxicity tests were applied for biological evaluation. Results and conclusion: Spectral changes supported coordination of HMSA through azo nitrogen and phenolic oxygen sites, with a different environment around each studied metal. XRD patterns changed after coordination, and FE-SEM also showed clear differences in particle form and dimensions. Among the antibacterial tests, Mn (II) gave the widest overall activity, whereas Ni (II) produced the largest inhibition toward E. coli. In the DPPH experiment, Ni (II) and Mn (II) generally gave stronger scavenging responses than free HMSA over the examined concentrations. HMSA and the Ni (II) complex both produced concentration-related effects on SK-OV-3 and normal HdFn cells.
Keywords
Antibacterial activity, Cytotoxicity, DPPH radical scavenging, Hydroxyazo ligand, Metal coordination complexes, SK-OV-3 cells
Recommended Citation
Abbood, Hussein Hayder and Waheeb, Azal Shakir
(2026)
"Synthesis, Spectroscopic Characterization, and Biological Evaluation of Ag(I), Ni (II), and Mn(II) Complexes with a Tridentate (N, O,O) Hydroxyazo Ligand,"
Muthanna Medical Journal: Vol. 13:
Iss.
3, Article 16.
Available at:
https://muthmj.mu.edu.iq/journal/vol13/iss3/16
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
