Relation of cytomegalovirus to alopecia areata: therapeutic trial with oral ganciclovire drug

Muthanna Medical Journal

Volume 7, Issue 1, 2020 Page 12-19

http://dx.doi.org/10.52113/1/2410-4590/2020-12-19

Research Article

Wisam Majeed Kattoof, Ahmed Abdulhussein Kawen

* Correspondence author: Wesam.majeed@uomustansiriyah.edu.iq

1Department of Dermatology – College of Medicine – AL-Mustansiriyah University, 2Department of Dermatology – College of Medicine – University of Thi-Qar

Received 11 January 2020, Accepted 4 April 2020, Available online 11 April 2020

This is an article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. Copyright © 2020 WK

Abstract

Alopecia areata (AA) is lost hair from a few or all regions of the body, for the most part from
the scalp. Etiology and pathogenesis of alopecia areata being not totally comprehended, is
accepted to be multifactorial in ancestry. Recently, studies suggested an association between
alopecia and types of viruses, therefore we concerned to investigate the association between
CMV infection and alopecia areata. This study included of 100 individuals (50 alopecia patients
and 50 healthy). Mean age of study groups were 20.90 ± 11.07 and 22.64±12.29 years of
cases and control group respectively. Mean of age onset of patients were 20.83 ± 10.0. Out
of 50 patients 52% were male, the rest were female. However, 1:1 of control group was male:
female. 40% of patients had a positive family history for this disease. Alopecia areata affected
on scalp in 78% of cases. All patients had a high concentration of CMV IgM. With treatment
of oral ganciclovire drug, a decrease of anti-CMV IgM levels and an increase of CMV IgG
levels were observed.
Keywords: Alopecia areata; CMV; IgM; IgG; ELISA

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