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Article Type

Article

Abstract

Background: Ewing Sarcoma is a challenging pediatric bone cancer with limited treatment options, particularly in advanced stages. Recent research has highlighted the potential of bone marrow-derived stem cells (BMSCs) as a novel therapeutic approach due to their tumor-targeting capabilities and ability to modulate the tumor microenvironment. Objective: This study aims to explore the therapeutic potential of BMSCs in the treatment of Ewing Sarcoma, focusing on innovative strategies that leverage their unique properties to enhance treatment efficacy and patient outcomes. Methods: This study involved a comprehensive review of the literature on BMSCs and their application in cancer therapy, with a focus on Ewing Sarcoma. Data was collected from peer-reviewed journals, clinical trial registries, and conference proceedings. The therapeutic mechanisms of BMSCs were categorized and analyzed based on their potential impact and research stage. Results: BMSCs demonstrated significant tumor-homing capabilities and reduced tumor growth in xenograft models. Molecular analyses revealed that BMSCs modulate key signaling pathways involved in tumor progression and immune response. The combination of BMSCs with standard therapies resulted in improved survival rates and reduced metastasis. Conclusion: Bone marrow-derived stem cells represent a novel and promising approach to the treatment of Ewing Sarcoma. While preclinical and early clinical studies have demonstrated their potential, further research is essential to translate these findings into effective therapies. Continued exploration of BMSC applications could lead to improved outcomes for patients with this challenging disease.

Keywords

Bone marrow-derived stem cells, Ewing Sarcoma, Novel therapeutic approach, Tumor microenvironment

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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