Assessment of Nutritional Status in Migraine Patients

Authors

Marwa Mohammed Ali Jassim, College of Dentistry, Al-Muthanna University, Al-Muthanna, IraqFollow
Abeer Mohammed Ali Al-Garawyi, College of Medicine, Al-Muthanna University, Al-Muthanna, IraqFollow
Hayder Saad Hanfoosh Alatabi, College of Dentistry, Al-Muthanna University, Al-Muthanna, IraqFollow

Article Type

Article

Abstract

Background: Migraine is the most common multidisciplinary and multifactorial neurologic disorder that is characterized by recurrent attacks of headache. Migraine occurs either in episodic or in chronic form, with or without aura. Recent research suggests that nutritional deficiencies, particularly Vitamin B12 deficiency, may play a role in the pathophysiology of migraines due to its impact on neurological function and homocysteine metabolism. Although its exact cause is still under investigation, recent studies suggest that vitamin D deficiency may play a role in migraine occurrence and severity. On the other hand, one of the main roles of Mg is to conserve neurons electric potential. Therefore, magnesium deficiency can cause neurological complications.

Subjects and Methods: A survey study was conducted for period of 4 months, starting from November/2024 to February/2025; the total number of participants were 50 subjects; laboratory tests were done by serological techniques of sandwich ELISA, were tested for specific serum (vitamin D3, vitamin B12 and magnesium).

Results: The results of the study illustrated the lower levels of VD3, VB12 and magnesium in migraine patients and presence of positive relationships between the studied markers and migraine. Furthermore, there were highly significant differences (P < 0.01) in the studied group regarding of vitamin D3, vitamin B12 and magnesium in relation to reference value.

Conclusion: The lowering level of serum (vitamin D3, vitamin B12 and magnesium) may be referring to presence a direct positive proportion with migraine. However, the authors of this study recommend studying other relevant parameters such as (blood lipid, Q10 and riboflavin). Furthermore, studying of inflammatory markers such as (Interleukin 17A, Interleukin 37 and Interleukin 38) in migraine patients because these parameters could be have strong association with migraine.

Keywords

Migraine, Vitamin D, Vitamin B12, Magnesium, ELISA

Recommended Citation

Jassim, Marwa Mohammed Ali; Al-Garawyi, Abeer Mohammed Ali; and Alatabi, Hayder Saad Hanfoosh (2025) "Assessment of Nutritional Status in Migraine Patients," Muthanna Medical Journal: Vol. 12: Iss. 2, Article 2.
Available at: https://muthmj.mu.edu.iq/journal/vol12/iss2/2

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This work is licensed under a Creative Commons Attribution 4.0 International License.