Article Type
Article
Abstract
Pharmaceutical stability is critical to ensuring medications efficacy and patient safety, particularly in prehospital environments where medication are exposed to extremely environmental conditions. This study evaluates the influence of temperature and light on medication permanency, focusing on medications that are frequently used in Advanced Life Support (ALS) settings, and inspects the medical physics belongings of degraded on liver and kidney functions as well as hematological considerations. Guidelines from the U.S. Pharmacopeia (USP) and Food and Drug administration (FDA) emphasize the significance of controlled storage conditions, nevertheless prehospital environments often exceed recommended temperature ranges (15–30°C). In vivo studies that compared fresh versus heat exposed Heparin and Insulin. Along with light exposed Nystatin in animal models, assessing liver enzymes (ALT, AST), kidney markers (urea, creatinine), and complete blood count (CBC). Exposed Heparin exhibited reduced anticoagulant activity, however Insulin presented elevated liver stress indications. Sunlight exposed Nystatin degradation led to considerable increases in ALT and AST, proposing hepatotoxicity. Hematological variations, including reduced white blood cells (WBC) and red blood cells (RBC) counts, were detected with both forms of evaluated medications, although exposed formulations frequently intensified these effects. These results highlight the risks of improper medication storage in prehospital caution, where temperature fluctuations and light exposure accelerated degradation. Therefore, this study give attractions and highlights the need for improved storage protocols, stability testing under real-world conditions, and enhanced packaging to relieve environmental effects. Confirming medication integrity in emergency medical services is essential for maintaining therapeutic efficacy and minimizing adverse patient concerns.
Keywords
Medical physics, Heparin, Insulin, Nystatin, Medications, Drugs
Recommended Citation
Alhasan, Ammar
(2025)
"Thermal and Photonic Stress Effects on Pharmaceutical Medications: A Medical Physics Evaluation Using In-vivo Models,"
Muthanna Medical Journal: Vol. 12:
Iss.
3, Article 6.
Available at:
https://muthmj.mu.edu.iq/journal/vol12/iss3/6
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
