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Article Type

Article

Abstract

Background: Cytokines mediate resistance to tuberculosis infection and play a significant role in host susceptibility and the progression of the infection. Aim: This study aimed to determine whether plasma levels of IL-17, IL-10, and VEGF can discriminate between non-resistant TB, monoresistant TB, Multidrug-resistant TB, and TB-negative subjects. Methods: Three hundred and twenty-five presumptive TB patients were recruited from 2020 to 2023 in the North-western region of Nigeria as study participants from whom sputum and blood samples were collected. The sputum samples were processed accordingly to detect drug-susceptible, monoresistant, and multidrug-resistant Mycobacterium tuberculosis (MDR-TB) using the Ziehl-Neelsen staining technique, GeneXpert, and Lowenstein-Jensen medium, based on which the participants were categorised into three groups: the drug-susceptible group, monoresistant group, and MDR-TB group. In contrast, the blood samples were used to determine the IL-10, IL-17 and VEGF plasma levels of all the groups using the Melsin ELISA test kit. Results: In all three groups, the plasma level of VEGF was the most elevated; however, there was a significant statistical association between IL-17, and VEGF when the groups were compared (p = 0.000). The Receiver operating characteristic curve (ROC) assessment for IL-10, IL-17, and VEGF showed that the area under the curve (AUC) for IL-17 was the highest for all the three groups (0.743, 0.858, and 0.99). Conclusion: This study indicates IL-17 as the best overall diagnostic performance as a discriminator between non-resistant TB, Mono-resistant TB and the MDR-TB group.

Keywords

IL-10, IL-17, VEGF, Tuberculosis

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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