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Article Type

Article

Abstract

Quercetin, a prominent dietary flavonol, exhibits a diverse range of biological activities that extend beyond simple free-radical scavenging, encompassing vital cytoprotective, membrane-stabilizing, and metabolic-regulatory properties.1 This comprehensive review elucidates the multifaceted pharmacological spectrum of quercetin in restoring physiological homeostasis under conditions of xenobiotic insults and metabolic stress.2 Specifically, we synthesize experimental and clinical evidence—including pivotal comparative studies to demonstrate quercetin's exceptional capacity to regulate systemic lipid profiles, preserve hemorheological parameters, and maintain cellular membrane integrity across vital systems.3,4 Furthermore, this review highlights the therapeutic efficacy of quercetin in mitigating industrial and environmental xenobiotic-induced toxicities, with particular emphasis on reproductive preservation, hematological stability,5,6 neuroprotective and endocrine modulatory role.50-62 By consolidating contemporary global literature with foundational comparative trials, this paper underscores the clinical potential of quercetin as a multi-targeted natural shield against systemic cytotoxicities and metabolic derangements, offering novel perspectives for integration into modern therapeutic regimens.

Keywords

Quercetin, Xenobiotic toxicity, Metabolic disorders, Lipid homeostasis, Neuroprotection, AMPK/Nrf2 pathways

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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